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Principles of behavioural toxicity testing.
The principles of behavioural toxicity testing are described and their application to different behavioural animal models discussed. The first is the concept of behavioural sensitisation, which describes the process of acquiring an acute state of behavioural response upon intermittent treatment with a repeated daily dose. This can be observed in the form of enhanced behavioural responses, such as increased locomotor activity, augmented attack behaviours and increased scratch response (allergies). First studies of sensitisation to novel psychopharmacological drugs, such as LSD, morphine, psychotomimetic agents and nicotine, began in the late 1950s. Of special relevance are sensit

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